• Medications that may increase the risk of sodium and fluid retention, such as corticosteroids. Remove the protective overpouch by tearing down from notch and remove container. Your doctor has weighed the risks of you being Before adding a drug, verify it is soluble and stable in water at the pH of the Sodium chloride 0.9 Infusion. To Open Last updated on Aug 1, 2020. To add medication before solution administration 1. Sodium Chloride Injection, USP is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Attach administration set. Sodium Chloride. Doses may be expressed in terms of mEq or mmol of sodium, mass of sodium, or mass of sodium salt (1 g NaCl = 394 mg, 17.1 mEq or 17.1 mmol of Na and Cl). Depending on the volume and rate of infusion, intravenous administration of Sodium Chloride 0.9% can cause: • Fluid and/or solute overload resulting in overhydration/hypervolemia and, for example, congested states, including central and peripheral oedema. If an administration set with a combined air inlet/fluid path connector has to be used, ensure the air inlet tube is always clamped off. Prime set and regulate administration as required. Select one or more newsletters to continue. Plasma electrolyte concentrations should be closely monitored in the paediatric population as this population may have impaired ability to regulate fluids and electrolytes. These chemicals are naturally present in A sterile non-pyrogenic intravenous infusion for administration to human beings. Do not remove unit from overwrap until ready for use. It does not contain all the available information. Do not connect flexible plastic containers in series in order to avoid air embolism due to possible residual air contained in the primary container. doctor the risks and benefits being given Sodium Chloride Injection or Intravenous • Drugs stimulating vasopressin release include: Chlorpropamide, clofibrate, carbamazepine, vincristine, selective serotonin reuptake inhibitors, 3.4-methylenedioxy-N-methamphetamine, ifosfamide, antipsychotics, narcotics, • Drugs potentiating vasopressin action include: Chlorpropamide, NSAIDs, cyclophosphamide, • Vasopressin analogues include: Desmopressin, oxytocin, terlipressin. The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly. Some medicines may affect the way sodium chloride works. Fig. If an adverse event occurs the patient should be evaluated and appropriate counter measures be started, if needed the infusion should be stopped. Serious The recommended dosage for treatment of isotonic extracellular dehydration and sodium depletion is: • For babies and children: 20 to 100 ml per 24h and per kg of body weight, depending of the age and the total body mass. The FLEBOFLEX plastic container is fabricated from latex-free polyolefins or polypropylene plastic materials. If use cannot be avoided, monitor fluid balance, electrolyte concentrations, and acid base balance, as needed and especially during prolonged use. depends on your condition and other factors, such as your weight, age, blood tests, The following adverse reactions have not been reported with this product but may occur: • Hypernatraemia (eg. The use of Sodium Chloride Injection, USP in pediatric patients is based on clinical practice. Do not add medication before hanger and ports have been straightened and the container inspected. 5. Please note that medical information found
Like other medicines, sodium chloride can cause some side effects. Additives may be introduced before infusion or during infusion through the injection site. Keep the reconstitution device attached to the drug vial. Caution: Do not store bags containing added medications. Administration of Sodium Chloride Injection, USP in patients treated concomitantly with medications associated with hyponatremia may increase the risk of developing hyponatremia. Do not be alarmed by this list of possible side effects. Brief exposure up to 40°C (104°F) does not adversely affect the product. It contains no antimicrobial agents. Discard any unused portion. When used in conjunction with cell separator procedures, there is a risk of air embolism or haemolysis. The inner bag maintains the sterility of the product. Pressurizing intravenous solutions contained in flexible plastic containers to increase flow rates can result in air embolism if the residual air in the container is not fully evacuated prior to administration. with your doctor. Mostly these are mild Before adding a drug, verify it is soluble and stable in water at the pH range of the Sodium Chloride 0.9% Intravenous Infusion solution. In such patients administration of Sodium Chloride 0.9% may result in sodium retention. Fig. 7. The solution is supplied in a plastic Viaflex container fabricated from PVC. The opacity will diminish gradually. 2. e. If administration set becomes blocked do not pump contents back into container but replace equipment. a. Sodium Chloride 0.9% should be administrated with special caution for pregnant women during labour particularly as to serum-sodium if administered in combination with oxytocin (see sections 4.4, 4.5 and 4.8). Visually inspect the container. Stop the infusion immediately if signs or symptoms of a hypersensitivity reaction develop, such as tachycardia, chest pain, dyspnea and flushing. Certain medications such as corticosteroids or corticotropin, may also increase risk of sodium and fluid retention, see Drug Interactions. To add medication during solution administration 1. 2. General adverse effects of sodium excess are described in section 4.9 Overdose. Some opacity of the plastic due to moisture absorption during the sterilization process may be observed. most are likely to be minor or temporary. A serum sodium concentration of 145 to 150 mEq/L may be targeted as this typically coincides with the desired reduction in intracranial pressure. In general, the risk of dilutional states (retention of water relative to sodium) is inversely proportional to the electrolyte concentrations of Sodium Chloride 0.9% and its additions. Do not administer unless solution is clear, free from visible particles and the seal is intact. 0.9% Sodium Chloride Injection, USP is also indicated for use as a priming solution in hemodialysis procedures. below 25°C. Sodium chloride systemic 1 gram (CMC 176). when administered to patients with nephrogenic diabetes insipidus or high nasogastric output), • Hyponatraemia, which may be symptomatic. Invert the drug vial above the Minibag Plus. ▪ renal disease (including renal artery stenosis, nephrosclerosis) or pre-eclampsia. on this website is designed to support, not to replace the relationship
The suitability of the container materials has been established through biological evaluations, which have shown the container passes Class VI U.S. Pharmacopeia (USP) testing for plastic containers. This site complies with the HONcode standard for trustworthy health information: verify here. Le chlorure de sodium est un composé chimique ionique de formule Na Cl.On l'appelle plus communément sel de table ou sel de cuisine, ou tout simplement sel dans le langage courant. Peel off the overwrap and remove solution container. Conversely, the risk of solute overload causing congested states (retention of solute relative to water) is directly proportional to the electrolyte concentrations of Sodium Chloride 0.9% and its additions. benefits they expect it to have for you. and short-lived. you are pregnant or intend to become pregnant, you are breastfeeding or plan to breast feed. 2. you are pregnant or intend to become pregnant, 3. you are breastfeeding or plan to breast feed. This is normal and does not affect the solution quality or safety. a. Swab the medication port with the appropriate anti-bacterial fluid in line with current recommended practice and procedure. This information is intended for use by health professionals, Sodium Chloride Intravenous Infusion BP 0.9% w/v, For the full list of excipients, see section 6.1. ), Risk of fluid and/or solute overload and electrolyte disturbances. The equipment should be primed with the solution in order to prevent air entering the system. For Information on Risk of Air Embolism – see DOSAGE AND ADMINISTRATION. Excessive administration of Sodium Chloride Injection, USP can cause fluid overload (which can lead to pulmonary and/or peripheral edema). your doctor will discuss the possible risks and benefit of being given Sodium Chloride Fig. 3. b. Repeated infusions of sodium chloride should therefore only be given after determination of the serum sodium level. burns, surgery, head-injury, infections), and concomitant therapy should be determined by the consulting physician experienced in paediatric intravenous fluid therapy (see sections 4.4. and 4.8). Special warnings and precautions for use).